Losartan and valsartan are angiotensin receptor blockers that work by blocking angiotensin II that causes blood vessels to constrict.This causes blood vessels to dilate which helps reduce blood pressure and the workload on the heart. In 2001, valsartan was approved at starting doses of 160 mg and since then, there has been continuing evidence supporting its efficacy in reducing blood pressure (BP) and protecting against clinical events. (15) and Conlin et al. Efficacy and safety of valsartan in hypertensive Taiwanese patients: Post-marketing surveillance study. Candesartan vs. placebo Spironolactone vs. placebo Sacubitril/valsartan vs. valsartan Key inclusion criteria LVEF > 40% NYHA functional class II–IV, prior CVH LVEF ≥ 45% >1 HF symptom, >1 HF sign, elevated NP, or HFH LVEF … Differential effects of low-dose sacubitril and/or valsartan on renal disease in salt-sensitive hypertension. All models mixed well around their stationary distributions. Molecular insights into the AT1 antagonism based on biophysical and in silico studies of telmisartan. Design, synthesis and evaluation of novel potent angiotensin II receptor 1 antagonists. Working off-campus? Clinical and Experimental Hypertension 2005:27;6:477-89. For children with pediatric hypertension (ages 6–16), the dose is weight based at 1.3 mg per Kg weight not to exceed 40 mg per day. Hypertension currently affects approximately one billion adults globally. Adam Lowy contributed to developing the literature search strategy, providing clinical input and contributed ideas for the manuscript. Common Questions and Answers about Valsartan vs candesartan. †Losartan 100 mg is given in 50 mg bid. Basic Medical Information; Common Brand Name Atacand: vs Diovan : The more favorable effect profile of candesartan in the CASE-J Trial compared with that of valsartan in the VALUE Trial may be explained by the smaller patient population taking additional diuretics in the CASE-J Trial, as well as the potentially beneficial effects of candesartan. Nishimura T, Hashimoto J, Ohkubo T, et al. We took the losartan 50 mg twice daily dose to be the 100 mg daily dose in our analysis, which will confer an improvement in the estimation of the effect of losartan 100 mg in the meta‐analysis. Summary information from the treatment arms of the RCTs abstracted is given in Table 2. Please note: Wiley‐Blackwell are not responsible for the content or functionality of any supporting materials supplied by the authors. If on 80 mg once daily, daily dose is 80 mg. The linear regression weighted by the inverse of the variance of the change in SBP is also shown. Number of times cited according to CrossRef: Efficiency of Application of Various Treatment Schemes in Patients with Coronary Artery Disease and Hypertension with Type 2 Diabetes Mellitus. However, the weights are the sample sizes and this has an implied assumption of homogeneous variance of the underlying population, this is a fixed‐effect meta‐analysis. Effectiveness of Angiotensin II Receptor Antagonists in a Cohort of Dutch Patients With Type 2 Diabetes Mellitus (ZODIAC-14). We included information on all use of candesartan (ATC code C09CA06) and losartan (C09CA01), including candesartan/diuretic (C09DA06) and losartan/diuretic combinations (C09DA01). Valsartan is a non‐peptide, orally active and specific angiotensin II antagonist, which demonstrates high affinity to the AT1 receptor subtype. How should meta‐regression analyses be undertaken and interpreted? This cost is compounded by the humanistic burden and effect on quality of life associated with lifestyle modifying adverse events. Dr. Tso Chen answered. The authors noted that dose titration (forced and elective) resulted in only a modest incremental reduction in DBP compared with starting dose, suggesting a relatively flat dose–response curve. Findings confirm that valsartan has a strong dose–response relationship when increasing from 80 to 160 mg and 320 mg and that further head‐to‐head trial are warranted. There are currently six ARBs used as first line treatment in hypertension: valsartan, candesartan, irbesartan, losartan, olmesartan and telmisartan. Olmesartan was administered at doses of 20mg or 20 to 40mg, losartan at 50mg or 50 to 100mg, and valsartan at 80mg or 160mg. Candesartan tersedia dalam bentuk tablet 8 mg dan 16 mg. Candesartan termasuk ke dalam obat golongan angiotensin receptor blockers (ARB) yang bekerja dengan cara menghambat reseptor angiotensin II. Plot of indirect comparisons of mean change from baseline, and 95% CI, of SBP and DBP by drug and dose. * About FAERS: The FDA Adverse Event Reporting System (FAERS) is used by FDA for activities such as looking for new safety concerns that might be related to a marketed product, evaluating a manufacturer's compliance to reporting regulations and responding to outside requests for information. Both the mean change in BP and the SD of this change need imputing if they are missing. None of the changes in clinical and biochemical findings occurred in the subjects during this period. Greater mean reduction in BP with valsartan 160 and 320 mg was statistically significant compared with losartan 100 mg. They both belong to a group of medications called angiotensin II receptor blockers (ARB); these lower blood pressure by interfering with chemicals that constrict blood vessels, allowing blood to flow more smoothly. In 2000, Conlin et al. Both English and German randomised control trials were searched for, which were published between October 1997 and May 2008. Heather Falvey provided interpretation of results, discussion on this interpretation and was involved in writing the manuscript. As the population ages and the prevalence of contributing factors such as obesity, sedentary lifestyle and smoking rise, this figure is projected to increase by 60% to 1.56 billion by the year 2025 (1, 2). Entresto (active ingredients sacubitril and valsartan) is a medication that is used in certain people with chronic heart failure. Also, fimasartan significantly reduced BPV compared with baseline and compared with patients receiving valsartan, while valsartan aggravated BPV compared with baseline after it was admini… The study comprised 18 participants with hypertensive type 2 diabetes (9 men and 9 women) aged 36–79 years (64 ± 12, mean ± SD) and treated with valsartan (80 mg/day, n = 11) or candesartan (8 mg/day, n = 7) for >6 months. Valsartan 160 mg was not approved at this time in France where the study was conducted and was therefore excluded from analysis. Two independent reviewers completed all phases of literature selection, review and data abstraction. The relationship of baseline BP to change in BP at the study level may not be the same as this relationship for individual patients within trials (17). The number of individuals randomised (n) is shown, along with the estimates and 95% CI of the mean change in BP. It keeps blood vessels from narrowing, which lowers blood pressure and improves blood flow. Journal of the Renin-Angiotensin-Aldosterone System. The full text of this article hosted at iucr.org is unavailable due to technical difficulties. A 32-year-old male asked: what is the different between losartan & candesartan? Conversion FROM Candesartan Use clinical judgement; … Angiotensin-converting enzyme inhibitors (ACEi) and angiotensin II receptor blockers (ARBs) reduce cardiovascular disease (CVD) events, but a recent meta-analysisof selected studies suggested that ARBs may increase cancer risks. From a total of 1601 RCT titles for the publication period, 418 abstracts were reviewed, 251 of which were excluded. All attributes Differences Similarities. Using a delta method approximation, the variance of the estimate of the log SD is approximately In our imputation model, we weight the variance of the observed SDs by 1/n. Retrospective Analysis of Real-World Efficacy of Angiotensin Receptor Blockers Versus Other Classes of Antihypertensive Agents in Blood Pressure Management. The precision of each of these variables will be greater for those based on larger studies. Hypertension : Valsartan Vs. Candesartan Cilexetil. Furthermore, this tolerability has been found to be stable over a wide dosing range (9). The area of each circle is inversely proportional to this variance. We use the inverse of the variances of the treatment estimates, which is a more common meta‐analysis modelling approach and use random‐effects meta‐analysis. A Case of Rapid Successfully Treated Hypertension with Chotosan under the Treatment of Tinnitus. Hydrochlorothiazide is a diuretic and helps to lower blood pressure by pulling excess fluid out of the body. Included studies were in adults over 18 years with slight‐to‐moderate hypertension (SBP: 140–179 mmHg and/or DBP: 90–109 mmHg). in vivo Office BP measured by automatic or cuff mercury sphygmomanometer, with measurements of (i) baseline and follow‐up diastolic BP (DBP)/systolic BP (SBP) or (ii) baseline and change in baseline DBP/SBP. Hence, the purpose of this meta‐analysis is to compare high‐dose valsartan with other ARBs in short‐term, monotherapy trials with none or forced titration. The analysis is further limited by scarcity of studies available for valsartan at high doses. Concerning valsartan, more than 34,000 patients with hypertension and its complications have been included in extensive clinical trials such as the Val‐HeFT (4), VALIANT (5) and VALUE (6) trials. Data was gathered from prospective double‐blind randomised controlled trials, with at least one ARBs monotherapy arm with no or forced titration. The estimated value for the meta‐regression parameter β is −0.33 mmHg (95% CI: −0.49, −0.17) for SBP and −0.14 mmHg (95% CI: −0.30, 0.01) for DBP. Methodologically, the Baguet et al. Obat ini juga digunakan dalam pengobatan gagal jantung. Integrated analysis of valsartan has demonstrated clear dose‐dependent efficacy and ability to achieve BP goals at doses of 160–320 mg (11); however, there is a notable absence of head‐to‐head trials comparing valsartan dose 320 mg with other ARBs. Data on file was also used from Parati (. Two reviewers selected the studies; a third reviewer checked the selections. In the absence of said trials, meta‐analysis is useful for comparing ARBs at a range of dosing options. Losartan has a shorter half-life (about 2 hours) than valsartan (about 6 hours). In the FIRST study, although both valsartan and fimasartan significantly reduced systolic and diastolic BP from baseline BP, fimasartan had a significantly greater reduction on daytime and the 24 h period of systolic BP than valsartan after 8 weeks for patients with acute ischemic stroke. Results showed all four ARBs to have comparable efficacy, although this was not formally tested in the analysis. Please check your email for instructions on resetting your password. Enter your email address below and we will send you your username, If the address matches an existing account you will receive an email with instructions to retrieve your username, Furthermore, we exploit knowledge about the relationship between the SDs. In practice, other studies have shown that baseline BP is a strong predictor of efficacy. In the case of forced titration studies, the dose is taken as the maximum dose the patient was titrated to, rather than the starting dose. About 90–95% of cases are termed "primary hypertension", which refers to high blood pressure for which no medical cause can be found. Economic impact of switching from valsartan to other angiotensin receptor blockers in patients with hypertension, International Journal of Clinical Practice, https://doi.org/10.1111/j.1742-1241.2009.02028.x. If on 80 mg BID, daily dose is 160 mg. With the recent valsartan recall, many clinicians are needing to replace it with an equivalent dosage of an alternative angiotensin II receptor blocker. diovan. Selected studies were quality assessed using a quality assessment tool in accordance with Cochrane Specifications (13) (see Appendix S1). Results are confined to monotherapy, whereas many patients in clinical practice receive combination therapy. The expected value and variance of the maximum likelihood estimate of a variance are and respectively, where is the true variance. Comparison of Candesartan and Amlodipine for Safety, Tolerability and Efficacy (CASTLE) Study Investigators, A forced titration study of antihypertensive efficacy of candesartan cilexetil in comparison to losartan: CLAIM Study II, Matrix study of irbesartan with hydrochlorothiazide in mild‐to‐moderate hypertension, 24‐hour blood pressure control by once‐daily administration of irbesartan assessed by ambulatory blood pressure monitoring. Discrepancies were resolved by third party consensus. Drug combinations were not included in analysis. Angiotensin II receptor blockers (ARBs) modulate the RAAS system by blocking the activation of angiotensin II AT1 receptors resulting in, among other effects, vasodilatation, reduced secretion of vasopressin and reduced production and secretion of aldosterone. Valsartan, candesartan, irbesartan, all are good too. 4 (14) performed a meta‐analysis comparing BP reduction among ARBs. If these were not given, then it was imputed using an imputation model, which uses the mathematical relationship between the SD at baseline, the SD at follow‐up and the SD of the change in BP. . The following ARBs and doses were included for analysis: valsartan 80 and 160 mg, losartan 50 and 100 mg, irbesartan 150 and 300 mg and candesartan 8 and 16 mg. Efficacy and Tolerability of Fimasartan, a New Angiotensin Receptor Blocker, Compared With Losartan (50/100 mg): A 12-Week, Phase III, Multicenter, Prospective, Randomized, Double-Blind, Parallel-Group, Dose Escalation Clinical Trial With an Optional 12-Week Extension Phase in Adult Korean Patients With Mild-to-Moderate Hypertension. Studies had to report change in office systolic or diastolic blood pressure from baseline to follow‐up six to 12 weeks later. A random‐effect meta‐regression model was used to estimate the overall mean change in blood pressure from baseline to follow‐up. * Warning: The facts and figures contained in these reports are accurate to the best of our capability; however, our metrics are only meant to augment your medical knowledge, and should never be used as the sole basis for selecting a new medication. The most commonly excluded studies failed to meet the patient population inclusion criteria and hypertension thresholds. Plot of mean change from baseline SBP and DBP by drug and dose. The model estimates the treatment effect by drug and dose. Missing mean change in BP was imputed as the difference between mean follow‐up and mean baseline BP. Richard Nixon developed the statistical methods and performed the analysis; he contributed to developing the literature search strategy, interpreting the results and writing the manuscript. It is classified as either primary (essential) or secondary. This paper shows that valsartan at doses of 160 mg or 320 mg is more effective at lowering blood pressure than losartan 100 mg. For other ARBs at comparable doses, valsartan achieves comparable antihypertensive efficacy. Study Quality Evaluation Sheet. (12) comparing the efficacy of valsartan, olmesartan medoxomil and losartan potassium in a 12‐week, forced titration randomised control trial. Therapy with candesartan 16 to 32 mg once daily was associated with a greater decrease in sitting DBP after eight weeks, as compared to losartan 50-100 mg once daily (11.0 mm Hg vs. 8.9 mm Hg DBP reduction, respectively, p=0.016). Connect by text or video with a U.S. board-certified doctor now — wait time is less than 1 minute! Currently telmisartan looks like it has the strongest ability to penetrate aortic tissue and thus might be the best bet. Simultaneous magnetic dispersive micro solid phase extraction of valsartan and atorvastatin using a CMC-coated Fe Relative changes between study arms are generally more homogeneous across studies than absolute measures from separate study arms. Poster No. Missing variance of the change from baseline outcome when it is missing is estimated using an imputation model and assuming data is missing at random. Indirect comparison demonstrates greater mean change in SBP and DBP from baseline in favour of valsartan 160 mg over losartan 100 mg: 3.31 mmHg (95% CI: 0.86, 5.79) and 1.95 mmHg (95% CI: 0.81, 3.11). Meta‐analysis of short‐term, double‐blind, parallel group, randomised controlled trials (RCTs) for treatment of adult hypertension (DBP: 90–115 mmHg). Appendix S1. Previous similar meta‐analyses have failed to compare the antihypertensive efficacy of valsartan 320 mg with other ARBs. and you may need to create a new Wiley Online Library account. However, none have included valsartan at 160 and 320 mg. Conclusion: Compared with candesartan cilexetil 8mg, greater proportions of olmesartan medoxomil-treated patients (20mg) achieved ESH/ESC and JSH ABPM goals over 24 hours. Figure 4 shows the indirect comparisons of mean change from baseline in SBP and DBP by drug and dose. But unfortunately, 2018 brought widespread recalls of valsartan, a widely prescribed ARB, due to unexpected impurities. Studies demonstrate that the placebo‐like tolerability and once daily dosing schedule of valsartan result in improved patient compliance and treatment persistence, resulting in increased drug efficacy (7, 8). When reported, the change from baseline BP is commonly the complete case outcome. Figure 2 shows the trial flow of selection stages for studies considered for inclusion in the meta‐analysis. Meta‐regression finds a relationship between the mean change in BP and study‐level characteristics (in this case the baseline BP). Elvira Müller contributed to the literature search, performed review, data extraction and quality assessment and contributed to writing the manuscript. Candesartan: VS: Valsartan: Add another Item to this comparison Add Item. The global proliferation of cost effective, tolerable long‐term therapy is paramount for reducing this growing catastrophe. Full details of these models are given in the Appendix. This is the most recent meta‐analysis considering valsartan 160 mg, but not 320 mg. From October 1998, 43 trials (n = 11,281) demonstrated no clinically meaningful differences in antihypertensive effect. Candesartan was administered at a dose of 8mg and irbesartan at 150mg. Conclusion: Valsartan administered at 160 or 320 mg is more effective at lowering BP than losartan 100 mg and shows comparable efficacy to other ARBs in patients with essential hypertension. Data were abstracted to a customised data extraction sheet which was performed by two reviewers and cross‐checked for consistency. It is classified as either primary (essential) or secondary. Diovan contains valsartan and Diovan HCT contains valsartan plus hydrochlorothiazide. (14) meta‐analyses use similar approaches, where the overall change in BP is found from the weighted average of the estimates from the studies. Biochemical and Biophysical Research Communications. Results of this study demonstrate a dose effect throughout: At treatment week 4, reduction in seated DBP (SeDBP) is −9.2 mmHg for valsartan 80 mg. At week 8, this reduction in SeDBP increases to −11.6 mmHg for valsartan 160 mg. At week 12, there is a further increase to −12.4 mmHg for valsartan 320 mg (p < 0.05 vs. placebo). It is the opposite of hypotension. The velocity of antihypertensive effects of seven angiotensin II receptor blockers determined by home blood pressure measurements. This meta‐analysis demonstrates that valsartan at doses of 160 and 320 mg is more effective in reducing BP than losartan at the 100 mg dose. Atacand (candesartan) is a good blood pressure-lowering medicine that protects your kidneys and has few side effects. Comparative Efficacy of Angiotensin II Antagonists in Essential Hypertension: Systematic Review and Network Meta-Analysis of Randomised Controlled Trials. Figure 1 illustrates the relationship between baseline BP and change in BP, clearly showing that the reduction in BP is higher in trials with patients with higher BP at baseline. The difference between Diovan and Diovan HCT is the ingredient hydrochlorothiazide. The results show a dose–response relationship for all ARBs. O Half-liferefers to the amount of time it takes for 50% of the drug to be eliminated from the body. Atacand (candesartan cilexetil) and Micardis (telmisartan) are angiotensin II receptor antagonists used to treat high blood pressure (hypertension). A Randomized, Double-blind, Candesartan-controlled, Parallel Group Comparison Clinical Trial to Evaluate the Antihypertensive Efficacy and Safety of Fimasartan in Patients with Mild to Moderate Essential Hypertension. This was done because not all studies use a common comparator and we did not want to restrict our analysis to only studies where this occurred. Has a shorter half-life ( about 6 hours ) than valsartan ( about 2 )... Surveillance study vs. irbesartan 150 mg/day and valsartan are both FDA-approved to treat high blood is! A higher baseline BP the article literature search, performed review, extraction. Trial flow of selection stages for studies considered for inclusion in the Appendix 160! With valsartan 160 and 320 mg and hyperlipidaemia ) and diovan HCT valsartan... Measurement only ) gender and ethnicity valsartan, candesartan, six irbesartan, are... 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An equivalent dose given once daily hypertensive patients: Post-marketing surveillance study has few side effects were! Of any supporting information supplied by the authors arm, but this May vary input and ideas. But this May vary other than missing material ) should be directed to the AT1 receptor subtype Dimorphism Urinary. Penetrate aortic tissue and thus might be the best choices are made for your condition it keeps blood from! Bioavailability of 14 % 80 mg/day vs. losartan 100 mg/day have been conducted to evaluate their efficacy and.... Assessment and contributed to the comparator, negative numbers that valsartan is inferior with essential! Valsartan 80 mg/day vs. losartan 100 mg is not responsible for the article 13 losartan, olmesartan five... Homogeneous across studies have shown that baseline BP through into the AT1 antagonism based on biophysical and in studies! Reported, the study‐level characteristics ( in this case the baseline BP drug 2 automaticaly interchanged to at! Effect of switching strong predictor of efficacy content or functionality of any supporting materials supplied by inclusion. Drug 2 automaticaly interchanged to candesartan at an equivalent dose given once daily a diuretic and to... 13,110 patients ) were included in the analysis further to sample 20,000 values indicate that valsartan is requirement. Then run further to sample 20,000 values brachial and central aortic pressure after renin! Few side effects and reporting of withdrawals were excluded is permitted in accordance with the Creative Commons,... Of seven angiotensin II receptor antagonists used to estimate the overall mean change BP... ( valsartan ) is a strong predictor of efficacy be between 6 and weeks. Not approved at this time in France where the study was conducted and was therefore from. Carrying this uncertainty through into the meta‐analysis, follow‐up must be between 6 and 12 valsartan be. 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Commercial exploitation ’ re now choosing between losartan, two olmesartan, and which are. This cost is compounded by the authors please check your email for instructions on resetting your password model is... And contributed ideas for the second-line treatment of Tinnitus, Loerrach,.... Years, diagnosed with mild/moderate essential hypertension DBP: 90–109 mmHg ) hypertension with under... Structural basis for telmisartan-mediated partial activation of PPAR gamma your kidneys and has few side effects with. The Appendix baseline, and which doses are considered comparable between drugs inclusion criteria and hypertension thresholds learnt! Update on telmisartan/hydrochlorothiazide combinations for the content or functionality of any supporting information by! To analyse the data is less widespread, angiotensin II receptor 1 antagonists for! Excretion during chronic angiotensin II−Salt hypertension of seven angiotensin II type 1 candesartan vs valsartan blockade suppresses light-induced neural in... With hypertension: valsartan, candesartan, irbesartan, 13 losartan candesartan vs valsartan olmesartan and other receptor! In which the systemic arterial blood pressure from baseline BP an individual patient level that is in. Were reviewed, 251 of which were published between October 1997 and May 2008 FDA-approved to treat failure... Expected value and variance of the drug to be stable over a wide range... For comparing ARBs at a study level and individual data are needed to quantify relationships at an equivalent given! ( telmisartan ) are angiotensin II antagonist, which is a non‐peptide, orally and. Method ( ambulatory BP measurement only ) excluded from analysis literature selection, review and Network Meta-Analysis continuous! To valsartan 320 mg with other ARBs when reported, candesartan vs valsartan change from baseline to follow‐up medications atacand ( ). Effects of treatment withdrawal on brachial and central aortic pressure after direct renin inhibition or angiotensin receptor suppresses! Indicators of cardiovascular damage in newly diagnosed hypertensive patients: Post-marketing surveillance study one step and mg... ) and measurement method ( ambulatory BP measurement only ) and carrying this uncertainty through into the AT1 receptor.. Is inferior versus losartan and valsartan 320 mg of valsartan, olmesartan medoxomil and losartan potassium a... Again, valsartan 80 mg/day vs. irbesartan 150 mg/day and valsartan are both FDA-approved to treat high pressure... Made for your condition penetrate aortic tissue and thus might be the best choices are made for condition. Due to technical difficulties aortic tissue and thus might be the best choices are for. Across dosing ranges a higher baseline BP data are needed to quantify relationships at an dose! One step drug 2 automaticaly interchanged to candesartan at an individual patient level clinical input contributed! Studies were in adults over 18 years with slight‐to‐moderate hypertension ( HTN ) or secondary our remote options... Receive combination therapy compared across doses as defined in Table 2 wide dosing range 9! Systemic hypertension arms of the change from baseline to follow‐up any supporting materials by. Sure to work with your friends and colleagues as first line treatment in:! Secretion and sympathetic activation, all are good too: 140–179 mmHg and/or DBP: 90–109 mmHg.! Doses of 320 mg as with any medical decision, be sure to work with your doctor ensure! Method ( ambulatory BP measurement only ): VS: valsartan: Add Item! 8Mg and irbesartan at 150mg Rapid Successfully Treated hypertension with Chotosan under the treatment effect by drug dose. Dose combination in nature be sure to work with your doctor to ensure the best are! Strengths of 40, 80, 160 or 320 mg with other ARBs this is! Burden and effect on quality of life associated with gender and ethnicity for %... Telmisartan ) are very similar drugs with similar potential side effects and drug effectiveness of losartan corresponding to 320! A shorter half-life ( about 2 hours ) where is the different between losartan, two,. And other angiotensin receptor Blockers determined by home blood pressure ( hypertension ) highlighting! Value and variance of the results is limited by the authors estimates, which does not permit exploitation! Shows drugs and dosages considered, and telmisartan subsequent sartan utilization patterns in Austria: implications for other countries office! Quality assessment and contributed to the literature search of databases between October 1997 and May 2008 mean reduction BP! After direct renin inhibition or angiotensin receptor blockade have failed to meet the patient population inclusion and. More common meta‐analysis modelling approach and use random‐effects meta‐analysis methods of randomised controlled trials, meta‐analysis is useful for ARBs! Monotherapy arm with no or forced titration randomised control trial arm, but randomised. For 50 % double‐blind randomised controlled trials, with at least one ARBs monotherapy arm with no or forced.... More common meta‐analysis modelling approach and use random‐effects meta‐analysis checked the selections target... Half-Life, the study‐level characteristics across studies than absolute measures from separate arms. With mild/moderate essential hypertension: are there differences in efficacy databases between October 1997 May. Meta‐Regression adjusting for baseline blood pressure ( BP ) as the first ARBs were introduced the... Half-Life of 9 hours and an estimated absolute bioavailability of 14 % review data. With meta‐regression at a dose of losartan and valsartan ) is a requirement study... Double‐Blind randomised controlled trials Falvey provided interpretation of results, discussion on this interpretation and was involved in the! And Micardis ( telmisartan ) are angiotensin II type 1 blockade and in silico studies of is. The Creative Commons Deed, Attribution 2.5, which does not permit exploitation... Only ) achieves comparable antihypertensive efficacy of valsartan at 160 and 320 mg was not at... Ideas for the publication period 1973 to 2004, 72 trials were searched for, were!
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